Research
UR
STUDIES
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Disease state clinical trials and case studies are omitted from this page
STUDY
No.1
The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial
Study Type
RCT
IMPLICATION
Anti-aging; DrinkHRW is an anti-aging agent that increases telomere length and improves DNA methylation. It also improves sleep quality and functioning in the elderly.
AUTHOR
Zanini, et al.
DURATION (DAYS)
180
year PUBLISHED
2021
DOSE
Anti-aging; DrinkHRW is an anti-aging agent that increases telomere length and improves DNA methylation. It also improves sleep quality and functioning in the elderly.
STUDY
No.2
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial
Study Type
RCT
IMPLICATION
Pre-hypertension, metabolic syndrome, central obesity; HRW reduced cholesterol, glucose, HbA1c, and markers of inflammation and oxidative stress. Mildly reduced body mass index and waist to hip ratio.
AUTHOR
LeBaron, et al.
DURATION (DAYS)
168
year PUBLISHED
2020
DOSE
11 mg H2/day;1 tablet 3 x daily in 250 mL of 12-18°C water, producing >5.5 mmol
STUDY
No.3
Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial
Study Type
RCT
IMPLICATION
NAFLD; reduced liver fat content and improved liver enzyme, especially AST, in overweight patients with NAFLD
AUTHOR
Korovljev, et al.
DURATION (DAYS)
28
year PUBLISHED
2019
DOSE
9 mg H2; 1 L/day of hydrogen rich water or placebo water
STUDY
No.4
Hydrogen vs. Caffeine for Improved Alertness in Sleep-Deprived Humans
Study Type
Cross over study
IMPLICATION
Sleep-deprivation relief; DrinkHRW improves alertness and executive function in sleep-deprived people with persistent results, while caffeine’s executive function improvement dropped after 15 min. DrinkHRW might be a better alternative to caffeine for fatigue and cognitive deficits from sleep deprivation.
AUTHOR
Zanini, et al.
DURATION (DAYS)
1
year PUBLISHED
2020
DOSE
9 mg H2; 1 L/day of hydrogen rich water or placebo water
STUDY
No.5
Hydrogen-rich water and caffeine for alertness and brain metabolism in sleep-deprived habitual coffee drinkers
Study Type
Cross over study
IMPLICATION
Sleep deprivation on cognitive function
AUTHOR
Todorovic, et al.
DURATION (DAYS)
1
year PUBLISHED
2021
DOSE
4 mg H2 and/or 50-mg caffeine; 4 Groups: 1) Drink HRW tablet (80 mg hydrogen-producing magnesium tablet, which gave rise to 8 ppm H2 in 500 mL lukewarm water) + 50-mg caffeine-free inulin powder, 2) DrinkHRW tablet + 50 mg caffeine, 3) 50 mg caffeine alone + non-hydrogen magnesium, and 4) placebo (non-hydrogen magnesium + caffeine-free inulin powder)
STUDY
No.6
The Influence of High Concentration Hydrogen-Rich Water for 24-Week on Body Composition, Blood Lipid Profiles, and Inflammatory Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Control Trial
Study Type
RCT
IMPLICATION
Metabolic syndrome
AUTHOR
Lebaron, et al.
DURATION (DAYS)
168
year PUBLISHED
2022
DOSE
>11 mg H2/day; 1 tablets 3x daily in 250 mL water @12 – 18oC water
STUDY
No.7
Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial
Study Type
RCT
IMPLICATION
NAFLD
AUTHOR
Kura, et al
DURATION (DAYS)
56
year PUBLISHED
2022
DOSE
>4 mg H2/day; 1 tablet in 330 mL of water 3x/day
STUDY
No.8
28-Days Hydrogen-Rich Water Supplementation Affects Exercise Capacity in Mid-Age Overweight Women
Study Type
RCT
IMPLICATION
Improved aerobic capacity, time to exhaustion, and total work completed during exercise.
AUTHOR
Ostojic, et al.
DURATION (DAYS)
28
year PUBLISHED
2018
DOSE
9 mg H2; 1 L per day with 9 ppm of H2
STUDY
No.9
Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study
Study Type
RCT
IMPLICATION
Reduced respiratory and heart rates during exercise, but no improvement in maximal exercise performance in young healthy adults
AUTHOR
LeBaron, et al.
DURATION (DAYS)
1
year PUBLISHED
2019
DOSE
5 mg of H2
STUDY
No.10
Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial
Study Type
RCT
IMPLICATION
Pain, swelling, ankle sprain recovery; 30 min ankle bathing every 4 h significantly relieved ankle sprain pain and swelling, and improved range of motion in 24 h.
AUTHOR
Javorac, et al.
DURATION (DAYS)
1
year PUBLISHED
2020
DOSE
8 ppm H2; 1) HRW was produced by putting a magnesium-producing formulation into a 3-L stationary whirlpool with
STUDY
No.11
The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease
Study Type
DB-RCT
IMPLICATION
H2 increases antioxidant capacity and CoQ10 in platelets in NAFLD patients.
AUTHOR
Sumbalova,et al.
DURATION (DAYS)
8
year PUBLISHED
2023
DOSE
8 ppm H2; 1) HRW was produced by putting a magnesium-producing formulation into a 3-L stationary whirlpool with
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STUDY
No.12
The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise
Study Type
DB- cross over study
IMPLICATION
Resistance training muscle damage and soreness; HRW can reduce muscle damage, and ease sore muscles after high-intensity eccentric exercise in active healthy men.
AUTHOR
Todorovic, et al.
DURATION (DAYS)
1
year PUBLISHED
2020
DOSE
8 ppm H2; A single session with super saturated HRW (8mg/L of H2) for 30 mins.
STUDY
No.13
The Effects of 12-week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial
Study Type
DB-RCT placebo- controlled
IMPLICATION
HRW may improve gut inflammation, improve the gut flora towards ones that produce more SCFA. The SCFA acts in the brain and mitochondria to help with body composition, metabolic health, and waist circumference in middle-aged overweight adults. N-acetylaspartate, a marker of neuronal functions, also went up in several brain regions.
AUTHOR
Korovljev et al
DURATION (DAYS)
84
year PUBLISHED
2023
DOSE
7.5 mg/day, divided into 2 doses
STUDY
No.14
The Effects of Medium-Term Intake of Hydrogen-Rich Water on Sperm Quality Biomarkers in Norospermic and Oligospermic Men: A Randomized Controlled Pilot Trial
Study Type
Pilot-RCT
IMPLICATION
Sperm quality and subfertility may improve with HRW
AUTHOR
Stager, et al.
DURATION (DAYS)
56
year PUBLISHED
2023
DOSE
15 mg/day, divided into 4 doses (freshly dissolved 1 HRW tablet in 250 mL water per dose per 6 h
STUDY
No.15
Hydrogen-Rich Water Upregulates Fecal Propionic Acid Levels in Overweight Adults
Study Type
Pilot-RCT
IMPLICATION
HRW can improve gut flora and postbiotics, especially propionic acid levels, in overweight adults. This may change microbiome towards better metabolic regulation.
AUTHOR
Korovljev et al
DURATION (DAYS)
12
year PUBLISHED
2023
DOSE
3 mg/day
STUDY
No.16
Molecular Hydrogen Modulates Brain Glutamate/GABA-Glutamine Cycle in Overweight Humans
Study Type
Pilot with historical controls
IMPLICATION
HRW may help reduce appetite by changing the glutamate-GABA-glutamine cycle in the brains of overweight humans, thus helping with weight loss.
AUTHOR
Korovljev et al
DURATION (DAYS)
84
year PUBLISHED
2023
DOSE
7.5 mg/day
CASE STUDY
No.1
Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete
Study Type
Case report
IMPLICATION
Concussion; Oral transmucosal hydrogen formulation within 15 min after the injury may reduce concussion symptom severity and improve recovery from the concussion.
AUTHOR
Javorac, et al.
DURATION (DAYS)
1
year PUBLISHED
2019
DOSE
700-mg tablet producing 80 mL of H2 administrated buccally every 2 hours
CASE STUDY
No.2
Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete
Study Type
Case report
IMPLICATION
Pain, swelling, and ankle sprin recovery; acute multi-session hydrotherapy with hydrogen-rich water might be a helpful treatment in terms of pain, swelling reduction and regaining range of motion after an ankle sprain.
AUTHOR
Javorac, et al.
DURATION (DAYS)
1
year PUBLISHED
2020
DOSE
8 ppm H2; 1) six sessions of ankle and foot hydrotherapy (e.g. 30-min at every four hours) with super-saturated hydrogen-rich water during the first 24 hours post-injury. 2) Super-saturated hydrogen-rich water was produced by putting a magnesium-producing formulation (10 g) into a 3-L stationary whirlpool with tap water of neutral temperature (20°C)
CASE STUDY
No.3
Supersaturated Hydrogen-Rich Water Hydrotherapy for Recovery of Acute Injury to the Proximal Phalanges on the 5th Toe: A Case Report
Study Type
Case report
IMPLICATION
Toe injury pain, swelling, and recovery; Soaking foot in high concentration hydrogen water can reduce pain, and improve function and recovery from a toe injury.
AUTHOR
Tarnava, A.
DURATION (DAYS)
7
year PUBLISHED
2021
DOSE
8 ppm H2; The case received four sessions (25 mins hydrogen rich hydrotherapy session) in a super saturated HRW with an average concentration 8mg/L.